Nano-Bio Materials Laboratory
Unusual low-dimensional DNA nanostructures were fabricated from DNA-b-poly(amino acid) through programmable and sequence-specific peptide interactions. Unlike prototypical DNA block copolymers, which typically form simple spherical micelles, DNA-b-poly(amino acid) assemble into various low-dimensional structures such as nanofibers, ribbons, and sheets through controllable amino acid interactions (ACS Nano 2020, 14, 2276).
Janus DNA nanosheets were fabricated from molecular building blocks composed of two information-carrying biopolymers, DNA and peptides. Experimental and structural modeling studies reveal that DNA1–peptide–DNA2 conjugates assemble into Janus nanosheets presenting two different DNA on opposite faces. The surprising level of structural control is attributed to the exclusive parallel β-sheet formation of phenylalanine-rich peptides. (Small 2021, 17, 2006110).